Directions Filling the Twice a Day Weekly Pill Organizer: It is preferable to fill your Twice-a-Day Weekly Pill Organizer once a week. Be careful to insert the proper regimen of dry medication into the color-designated and highlighted AM and PM compartments. Cleaning the Twice-a-Day Weekly Pill Organizer: Top rack dishwasher safe. First detach both the AM and PM 7 lid sets from the Twice-a-Day Weekly Pill Organizer base. Lay both the Twice-a-Day Weekly Pill Organizer and the AM and PM weekly lid sets securely on the top rack of dishwasher.